Tag Archives: Porcine tissue research

Three baboons sitting on a tree

Baboons Live Six Months Following Porcine Heart Transplant

With wait times for human organs as long as several years (at which point it may be too late for the designated recipient), the medical community has turned to animal organs as potentially life-saving alternatives.  Recent developments in gene editing such as CRISPR may someday lead to porcine hearts being a viable option for cardiac patients.  

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Porcine Tissue Used for Vitreous Cryopreservation Research

PigletVitreous cryopreservation is a practice that allows for the preservation of biomaterials without the risk of excess ice accumulation.

Porcine tissues are an excellent model for this sort of research. There are many stresses – internal, thermal, residual – induced by the rapid cooling process of vitreous cryopreservation.

By using porcine tissues, researchers can fine-tune the methods used in cryopreservation and improve the process, which in turn will allow for effective preservation of larger materials.

Since porcine hepatic tissue is so similar to the liver tissue found in humans, it is an excellent tissue model for vitreous cryopreservation research. A recent study in China – published in the March 2017 edition of the International Journal of Heat and Mass Transfer — used porcine hepatic tissue to look at vitreous cryopreservation.

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How Porcine Tissue May Help Liver Transplant Patients

Two pigletsHernias occur after about 30 percent of orthotropic liver transplants, or OLT.

As discussed earlier this year in the Germany Journal of Gastroenterology, a group of Austrian researchers looked at this problem and found that use of porcine non-cross-biological patches seemed feasible for hernia repair after OLT.

The study notes that “wound infections in these patients have been observed with other meshes. Further investigation is needed to prove potential superiority of this biological to the other meshes.”

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What Porcine Enzymes and Mice Tell Us About Blood Brain Barrier Dysfunction

iStock_000012327217_SmallChronic obstructive pulmonary disease (COPD) shows progressive, irreversible airflow limitation induced by emphysema and lung inflammation. The aim of this study was to determine if COPD conditions induce blood-brain barrier (BBB) dysfunction.

They found that intratracheal administration of porcine pancreatic elastase induced alveolar enlargement, increased neutrophil numbers in bronchoalveolar fluid and decreased blood oxygen saturation in mice at 21 days post inhalation. At the same time BBB permeability to sodium fluorescein and Evans blue albumin was markedly increased concluding that COPD conditions are associated with risk for BBB impairment.

— From Elevated permeability of the blood-brain barrier in mice intratracheally administered porcine pancreatic elastase by Fuyuko Takata, Koji Tominaga, Mitsuhisa Koga, Shinya Dohgu, Koujiro Futagami, Atsushi Yamauchi, Yasufumi Kataoka

This study shows one of the many ways porcine models can aid in human health breakthroughs. In the past, researchers have used porcine  tissue to repair human tendons.

Porcine Tissue Can Help Study Marfan Syndrome

porcine tissuePorcine post mortem tissues could be used to augment ATAA (ascending thoracic aortic aneurysm) studies in human normal and Marfan syndrome patients, according to research at the University of Western Ontario’s Department of Medical Biophysics.

In this study the human tissues had to be retrieved from human patients undergoing invasive bypass surgeries as well as from human cadavers. Marfan syndrome is a genetic disorder that affects the body’s connective tissue, and can cause issues with a person’s heart, blood vessels, bones, joints, and eyes.

Because of the anatomical and physiological similarities of porcine to human aortic arteries, post mortem porcine tissue could be substituted experimentally for human tissue thus greatly reducing the time and expense of the research studies.

In the past, porcine tissue has also been used to repair rotator cuffs in human patients, and to regrow muscle tissue.

For over 25 years, Animal Biotech has helped the biomedical community with this sort of research by supplying it with live high quality research porcine models along with high quality post mortem tissues, organs, and glands. We also provide information, consultation and training on most aspects of husbandry, testing, housing and uses of live animals. Contact us today to learn more about how we can assist you in your work.


Porcine Tissue Can Repair People’s Injuries

porcine tissuePorcine tissues are very close to human tissues so it is natural to think that porcine tissues can be used to repair or replace human tendons and ligaments.

In his article “Animal Tissue Will Build Ligaments and Tendons of the Future,” Dr. Kevin Stone explains how well porcine tissues repair torn human tendons and ligaments and actually makes them stronger than the original tissue.  He writes:

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How Domestic Pigs Can Help Cure Human Ailments

porcine tissueThe purpose of animal research is to derive scientific information from animal models that will be used to benefit human health and wellness.

The domestic pig (Sus scrofa) is one of the most valuable animal models used in biomedical research today,  both as a live animal and also as a source of post mortem tissues. This is because of its lower cost, larger size and anatomical, biological and physiological similarity to humans.

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Porcine Tissue Used to Grow Human Skeletal Muscle Tissue

Pigs are a major contributor to the biomedical research world. A new method of using porcine bladder tissue to create human muscle repair using a stem cell technique is proof. The University of Pittsburgh School of Medicine and The McGowan Institute for Regenerative Health has been testing this procedure in clinical studies and found that it works. This technique actually causes functional skeletal muscle to be formed where only scar tissue would normally form and the new muscle fibers actually secure their own blood flow. This tissue was used in the past to repair hernias and ulcers on the skin. Click on the link below to read the full article “Patients Regrow Muscles with Pig Bladder Tissue” written by Jessica Firger of CBS News.

Biosecurity Programs for the Control of PEDv in U.S. Domestic Swine

Animal Biotech

Since our last update on PEDv, several new facts have come to light. The disease continues to spread throughout the U.S., especially the Midwest where it is having a major impact on the pork industry. It is also known to exist in the northeast including Maryland and Pennsylvania. More and more producers are having their production units devastated and shortages of swine for slaughter are driving up domestic pork prices in supermarkets.

No information is currently available as to whether this disease has reached the biomedical research community which is why users of swine must have a biosecurity plan in place for the prevention of PEDv.

Although reporting is voluntary, research institutions should be aware of their sources of swine and inquire as to whether PEDv exists in their herds.

Equally important, each research institution should have a Biosecurity Program in place to not only protect itself from getting PEDv, but one that helps prevent the spread of the disease within the research institution in the event there are infected swine already present. ABI remains negative for PEDv and is highly proactive in having each of its clients establish a Biosecurity Program for the protection of its own pigs at the time of delivery. Continue Reading Biosecurity Programs for the Control of PEDv in U.S. Domestic Swine

A Focus on Quality Tissue for Research Needs

Highest Standards of Animal Tissue Harvesting

At Animal Biotech Industries (ABI), our mission is to provide clients with high-quality, post-mortem tissues harvested with precise attention to client specifications. All products are harvested at USDA federally inspected abattoirs or at our onsite climate controlled facilities. These harvests are carried out in strictly controlled environmental conditions following precise protocols which have been specifically developed for each client.

Animal Tissue Shipment

These tissue samples are then processed and packaged using time tested techniques that guarantee the integrity of the tissues during shipment. Most tissues are shipped by FedEx either fresh using cold packs or frozen with dry ice. Our packaging and boxing methods allow all tissue to remain in either condition during shipment inside the boxes for up to three days even under the most adverse temperature extremes. We also make it our policy to have contingency plans in place to ensure our clients receive their tissue exactly when they need it, taking into account possible delivery delays with intermediate shipping companies. All FedEx boxes are tracked by both ABI and its clients. Continue Reading A Focus on Quality Tissue for Research Needs