Tag Archives: porcine cells

Live Animal Model: Pigs in Virus Research

Corona Virus

Research swine are playing an important role in the global fight against COVID-19, with live animal models helping to both create a vaccine and address the worldwide ventilator shortage.

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How Porcine Cells Contribute to Restorative Therapies

close-up of pig - porcine cells being used in restorative therapies

Research swine are contributing to research studies that focus on restorative therapies to replace lost or diseased human tissues.

While the amount of suitable human cells for transplantation is lacking, porcine cells offer researchers a suitable, and much more available, alternative.

In 2014, researchers from the University of Pittsburgh found that cells derived from porcine organs – in this case, bladders – could work with human stem cells help build muscles in the legs of five men who had suffered severe injuries, including two soldiers injured by IEDs.

All five had suffered from nearly 60 percent to 90 percent of leg muscle loss, and had undergone surgery and physical therapy, with no success.

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Study Shows Porcine Cells Can Help Wound Healing

An acellular cholecyst extracellular matrix (p-CEM) of porcine origin was prepared using iStock_000002065074_Smallanionic biological detergent and the healing potential compared with commercially available collagen sheet (b-CS) and open wound (C) in full-thickness skin wounds in rats.

Healing was evaluated on the basis of wound contraction, gross, hematological, immunological and histopathological observations. It was found that p-CEM had healing potential and was shown to have a better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.

This study illustrates the better healing qualities of porcine extracellular matrix when compared to commercially available collagen sheets and open wound in full-thickness skin wounds in rats.

— From Porcine cholecyst derived extracellular matrix (p-CEM) for reconstruction of full thickness skin wounds in rats. Poonam Shakya et al. Wound Medicine, Vol 10-11, December 2015, Pages 23-31. Copyright 2015 Elsevier B.V.

This research is just the latest study using porcine materials to advance medical treatment. Past studies have used pig models to look at repair to damaged hearts and genome reprogramming.

At Animal Biotech, we’re proud to be a part of this kind of work. For more than 20 years, we have supplied the biomedical research community with live porcine models and post-mortem tissues, along with expert consultation and information. Contact us today to find out how we can assist you in your work.

How Porcine Stem Cells Relate to Genome Reprogramming

porcine stem cellsThe limited success of somatic cell nuclear transfer (SCNT) is largely attributed to defects in epigenetic reprogramming of the donor genome.

Donor cell types with distinct potential competence may offer different epigenetic flexibility for subsequent genome reprogramming in SCNT.

To improve the efficiency of cloning, porcine mesenchymal stem cells (pMSCs) were isolated and well identified by 6-channel flow cytometry and differentiation assays and were used as donors in SCNT.  The results suggest that the epigenetic status of donor cells has an improvement on genome reprogramming, and multipotent pMSCs favored subsequent embryonic development.

From Porcine Mesenchymal Stem Cells: Establishment, Differentiation, Electroporation and Nuclear Transfer, by Song, Z., Cong, P., Ji, Q., Chen, L., Nie, Y., Zhao, H., He, Z. and Chen, Y. (2015).  Reproduction in Domestic Animals, 50: 840-848. doi: 10.1111/rda. 12577

At Animal Biotech, we’re proud of our nearly three-decade history of supporting this sort of research by providing the biomedical community with  live high quality research porcine models as well as high quality post mortem tissues, organs, and glands.

Contact us today to find out more about how we can help you with your next project.