The concept of xenotransplantation between humans and pigs is not new, but it’s one that’s faced some hurdles on the road to becoming a viable organ transplant method.
The key concern was that the human recipient could contract serious – if not fatal – zoonotic diseases from pig organs via porcine endogenous retroviruses (PERVS).
Continue Reading Xenotransplantation: How Pig Organs Could Be Transplanted into Humans
Research swine are playing an important part in the understanding of role of the extracellular matrix (or ECM) scaffold of the pancreas, which in turn helps advance regenerative medicine as it applies to restoring the of pancreas’ endocrine function.
Continue Reading How Research Swine Are Used in Decellularization/Recellularization Technology
Pedicle screws have been the standard method of treatment of spinal diseases.
However, these screws can loosen over time after placement during surgery, which makes them a less-than-ideal choice.
But how can surgeons improve on this practice? The answer may lie within research swine. More specifically, within pig lumbar spines.
Continue Reading Pig Lumbar Spines Used for Pedicle Screw Testing
Skin permeation studies are extremely important in predicting percutaneous penetration, and porcine tissue models have proven very important in such research.
A recent study conducted at the University College of London compared skin parallel artificial membrane permeation assay (PAMPA), porcine skin and human skin in the permeation of compounds topically placed on each tissue/artificial tissue.
Continue Reading Studying Skin Permeation with Porcine Tissue Models
If there’s one thread that runs through all our blog posts, it’s the physiological similarity between pigs and humans, a fact that makes the porcine model extremely useful in biomedical research.
For example, there’s the study conducted by researchers at South China Agricultural University and the University of Hawaii at Manoa that looked for the presence of brown adipose tissue (BAT) in pigs.
Continue Reading Determining the Presence of Brown Adipose Tissue in Porcine Models
Wireless capsule endoscopy has been very helpful in making advances in the world of endoscopy, but this work has always been limited to superficial tissue.
However, a there is a new method of pairing ultrasonography with the wireless capsule, allowing doctors to view deeper levels of tissue and therefore have a clearer view of all the tissues involved in the endoscopic procedure.
Continue Reading Porcine Model Used for Wireless Capsule Endoscopy Research
The porcine model has proved to be helpful in establishing the therapeutic effects of mesenchymal stem cells (MSC) in reducing the inflammatory response during acute lung injuries.
In a study conducted at the Tripler Army Medical Center in Honolulu, researchers determined that pigs induced with severe traumatic lung injuries had decreased PVR/SVR levels two hours after treatment with MSCs.
Continue Reading Porcine Model Used for Acute Lung Injury Research
Porcine heart tissue may prove extremely helpful in finding a solution for cardiac failure.
The process of using detergents to decellularize and then recellularize porcine hearts with differentiated cells made from human patient specific pluripotent stem cells is an innovative area of research that may significantly change the prognosis for heart failure patients.
Continue Reading Finding a Solution for Cardiac Failure with Porcine Heart Tissue
Americans spend more than $20 billion dollars a year on wound care, a figure that’s exacerbated by factors such as infections, repeated surgeries and extended hospital stays.
With that in mind, researchers are seeking innovative ways to enhance wound management. One such method is the porcine urinary bladder matrix.
Two recent studies have shown the effectiveness of porcine tissues in treating wounds in both humans and other animals.
Continue Reading Porcine Urinary Bladder Matrix Used to Treat Wounds
Tissues prepared for shipment.
As we discussed last month, abalation is a method used in treating liver tumors. Our previous blog post looked at thermal abalation and porcine liver tissues.
This week, we’ll look at microwave abalation (MWA) in liver tumor treatments and a study by Italian researchers published in 2015 in the Journal of Cancer Surgery.
Continue Reading Microwave Ablation Study Using Porcine Liver