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Category Archives: Porcine tissue research

Porcine Tissue Remodeling & Ingrowth

Porcine Tissue Remodeling & IngrowthSurgeons that perform tendon and ligament replacements are always searching for materials that can mimic the performance and load transmissions of the native material.

As often happens, these searches turn to porcine tissue to approximate human tendons.

In a U.S. patent application filed in 2016, LifeCell Corporation of Branchburg, NJ describes a study using a porcine acellular tissue matrix – derived from porcine skin – that was implanted into a human.

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Biocompatible Mesh Graft from Porcine Dermal Tissue

porcine dermal tissueThe cells that make up our bodies are surrounded by an extracellular matrix – ECM – which provides support for the cells.

When there is damage to the cells, tissue must be regenerated. This regeneration depends on a series of physiological events.

The first stage of this process is the inflammatory phase. After many other cells migrate to the damaged site, the differentiated cells produce and deposit new extracellular matrix.

Studies, such as the one published last year by LifeCell Corporation in New Jersey, have used porcine dermal tissue to make a biocompatible mesh to repair multiple damaged tissues, while minimizing infections or adhesions.

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A Study of Ultrasound Elastography Using Porcine Renal Tissue

Animal Models with Porcine Renal TissuePorcine renal tissue is useful in studying ultrasound elastography, a method of measuring the graft health of a transplanted kidney.

A recent study by researchers at the University of British Columbia found that blood pressure plays a role as a confounding factor in measuring the elasticity of the renal tissue.

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Studying Injectable Biomaterials on Porcine Tissue

injectable materials for porcine tissueAs we’ve pointed out multiple times on this blog, porcine tissue is used in research because of pigs’ biological similarities to humans.

That was the case yet again in a study conducted by researchers from the Departments of Chemical Engineering and Biological Sciences at Rowan University and the Department of Biomedical Engineering at Drexel University.

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Porcine Models and Pancreatic Cancer Research

Pig curiosityPancreatic research is – quite literally – a matter of life and death.

Problems with the pancreas can lead to diabetes, and people with diabetes have a higher risk for pancreatic cancer.

And pancreatic cancer is among the deadliest forms of the disease. It develops quickly, is difficult to detect early and hard to treat, and has a five-year survival rate of just six percent.

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Porcine Tissue Used in Spinal Cord Injury Research

porcine tissue for spinal researchIt is both interesting and refreshing to look at the field of regenerative medicine from the perspective of biomechanical engineering research, rather than the standard cellular and biological aspects.

Regenerative medicine is a very exciting field of study, and the porcine lends itself very well to this type of research. That’s because – as we have pointed out before – of the biological similarities between pigs and humans.

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Regenerative Medicine Research With Porcine Skin Tissue

porcine skin tissue research modelToday we’ll discuss yet another example of the similarities between human and porcine skin tissue in terms of wound healing.

Pressure ulcer prevention is important for healing, and the porcine model is an integral part of research into this subject.

Among that research is a study published in October in the journal Wound Repair and Regeneration. As the authors of the study note, 2.5 million patients develop pressure ulcers each year in America, with treatment costs exceeding $11 billion.

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Pigs Useful in Obesity and Immune Research

HHumans and pigs are biologically similar enough for research that the latter help make medical breakthroughs to help the former.

But a new project at Maryland’s Agricultural Research Services is looking at pigs in a way aimed at promoting both human and animal health.

The work is being done by nutritionist Harry Dawson and microbiologist Gloria Solano-Aguilar, who are studying the effect of nutrition on immune and inflammatory responses at the ARS’s Beltzville Human Nutrition Research Center.

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How Porcine Tissue May Help Liver Transplant Patients

Two pigletsHernias occur after about 30 percent of orthotropic liver transplants, or OLT.

As discussed earlier this year in the Germany Journal of Gastroenterology, a group of Austrian researchers looked at this problem and found that use of porcine non-cross-biological patches seemed feasible for hernia repair after OLT.

The study notes that “wound infections in these patients have been observed with other meshes. Further investigation is needed to prove potential superiority of this biological to the other meshes.”

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