The University of Maryland Medical Center announced yesterday that David Bennett, the first successful recipient of a transplanted porcine heart, died at the age of 57. An exact cause of death was not provided, though the physicians noted that his condition had been deteriorating over the previous several days.Continue Reading Update: First Human Recipient of Pig Heart Transplant Dies
In a breakthrough years in the making, 57-year-old Dave Bennett has become the first human recipient of an organ from a genetically edited porcine donor. The nine-hour procedure took place at the University of Maryland Medical Center under the leadership of surgeon Bartley Griffith. Bennett, who began experiencing severe chest pain in October, was not eligible to receive an artificial heart pump or human heart transplant. Knowing it was his best chance at survival, he agreed to the experimental surgery, and in the process has made history.Continue Reading Milestone: Human Patient Receives Pig Heart Transplant
Research swine are playing an important role in the global fight against COVID-19, with live animal models helping to both create a vaccine and address the worldwide ventilator shortage.
Thermal ablation is an important technique in treating liver tumors and metastases. New research into this treatment conducted in Germany relied on porcine liver models to test ablation methods.
This study was conducted by researchers from University Medicine Berlin and Martin Luther University in Halle, and published in April in the Journal of Cellular Biology.
Orthopedic surgeons are finding a rapid repair for rotator cuff tendon injuries where there was not a reliable method in the past. Porcine intestinal tissue has been determined to make a viable patch which allows the surgeons to have tissue to suture the tear together and aids in stimulating the body to grow new tendon tissue. The pig tissue, which is mostly collagen, then is absorbed by the body. This finding was reported by ABC News’ Denise Dador and ABC News.com’s Robin Eisner. Please click the link to read the article “Pig Intestinal Tissue Helps Human Injury.”
Pigs are a natural source for xenotransplantation due to the fact that they are so anatomically similar to humans. The key is to genetically modify the animals by knocking out the genes that are responsible for initiating the human immune system.
Research studies that have been carried out over the last year at The National Heart, Lung and Blood Institute (NHLBI) have shown that genetically altered porcine hearts that are transplanted into baboon’s abdomens are withstanding rejection along with a little help from host targeted immunosuppression. It is the hope of the scientists that all major organs will be able to be xenotransplanted including insulin producing cells which would treat diabetic patients.
This procedure will hopefully mean fewer potentially toxic drugs for immunosuppression. This is critical research because it may solve the shortage of human donor organs. Please click the link for “Pig Heart Transplants For Humans Could Be On Their Way” by Janet Fang to read the article.
Since our last update on PEDv, several new facts have come to light. The disease continues to spread throughout the U.S., especially the Midwest where it is having a major impact on the pork industry. It is also known to exist in the northeast including Maryland and Pennsylvania. More and more producers are having their production units devastated and shortages of swine for slaughter are driving up domestic pork prices in supermarkets.
No information is currently available as to whether this disease has reached the biomedical research community which is why users of swine must have a biosecurity plan in place for the prevention of PEDv.
Although reporting is voluntary, research institutions should be aware of their sources of swine and inquire as to whether PEDv exists in their herds.
Equally important, each research institution should have a Biosecurity Program in place to not only protect itself from getting PEDv, but one that helps prevent the spread of the disease within the research institution in the event there are infected swine already present. ABI remains negative for PEDv and is highly proactive in having each of its clients establish a Biosecurity Program for the protection of its own pigs at the time of delivery. Continue Reading Biosecurity Programs for the Control of PEDv in U.S. Domestic Swine
The USDA has confirmed that porcine epidemic diarrhea virus (PEDV) has been identified in the United States for the first time, through testing at the National Veterinary Services Laboratory. This is not a new virus, nor is it a regulatory/reportable disease. Since PEDV is widespread in many countries, it is not a trade-restricting disease, but rather a production-related disease. PEDV may appear clinically to be the same as transmissible gastroenteritis (TGE) virus with acute diarrhea. This PEDV is not zoonotic and poses no risk to the meat industry. An outbreak, however, can be devastating in swine production as well as research facilities with death rates of 30-100 percent in young pigs. PEDV spreads mostly by ingestion of contaminated feces. The most common sources of infected feces are pigs, trucks, boots, clothing, or other inanimate objects such as vehicles, trailers, or transfer equipment. Cleaning, disinfection, and drying of contaminated surfaces are effective measures to prevent PEDV contamination. PEDV is susceptible to many common disinfectants such as Clorox, virkon-s, 1 stroke, tek-trol and others. Producers as well as end users need to develop and maintain strict biosecurity protocols in order to prevent the virus from affecting domestic swine used in biomedical research. We have been working with our veterinarian and government sources to protect our herd via monitoring and the continual upgrading of our biosecurity program.
Please note that ABI is free of PEDV due to a very strict biosecurity plan which has been in place since October 2013. A strict quarantine program exists where no replacement animals, animal based feed products, commercial or agricultural vehicles, visitors, or any other potential vectors, etc. can enter the ABI production facility. In order to expand our biosecurity efforts, we are requesting that all of our clients do two things: Continue Reading Animal Biotech Research Swine Free of PEDV
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