Osteoporotic patients, incapacitated due to vertebral compression fractures (VCF), suffer grave financial and clinical burdens because current clinical treatments focus on symptoms’ management but do not combat the issue at the source.
In this pilot study, allogeneic porcine mesenchymal stem cells, (over expressing the BMP6 gene) were suspended in fibrin gel and implanted into a vertebral defect to investigate their effect on bone regeneration in a clinically relevant, large animal pig model. Bone healing was evaluated in vivo at 6 and 12 weeks and ex vivo at 6 months.
Both exams showed significant bone regeneration within 6 weeks of implantation in the BMP gene group while only minor bone formation was seen in the defect site of the control group. This preclinical study presents an innovative, potentially minimally invasive technique that can be used to induce bone regeneration using allogeneic gene modified MSCs and therefore revolutionize current treatment for challenging conditions such as osteoporosis-related VCFs.
From BMP6-Engineered MSCs Induced Vertebral Bone Repair in Pig Model: A Pilot Study by Gadi Pelled, Dmitriy Sheyn, Wafa Tawackoli, Deuk Soo Jun, Youngdo Koh, Susan Su, Doron Cohn Yakubovich, Ilan Kallai, Ben Antebi, Xiaoyu Da, Zulma Gazit, Hyun Bae and Dan Gazit
Animal Biotech is proud to provide support for this sort of scientific work. For over 25 years, we have helped the biomedical research community by supplying it with live high quality research porcine models as well as high quality post mortem tissues, organs, and glands. We also supply information, consultation and training on most aspects of husbandry, testing, housing and uses of live animals. Contact us today to learn more about how we can assist you in your work.