All posts by abtadmin

Three baboons sitting on a tree

Baboons Live Six Months Following Porcine Heart Transplant

With wait times for human organs as long as several years (at which point it may be too late for the designated recipient), the medical community has turned to animal organs as potentially life-saving alternatives.  Recent developments in gene editing such as CRISPR may someday lead to porcine hearts being a viable option for cardiac patients.  

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simple rendering of human lungs in shades of blue

Porcine Organ Block as a Thoracoscopic Lobectomy Model

In medical disciplines such as surgery, it is crucial for practitioners to have hands-on experience with procedures before performing them in a clinical setting.  This is easier said than done: certain operations are difficult to replicate outside of a living subject.  It can also be difficult to access and learn on practice models outside of an educational setting, posing a problem for practicing surgeons who want to utilize techniques developed after the completion of their education.  Animal models and tissues provide one solution to this problem, allowing students and professionals to develop their skills on non-human subjects.  This article from The Annals of Thoracic Surgery describes one such simulator for the practice of thoracoscopic lobectomy.

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David Bennett and family

Update: First Human Recipient of Pig Heart Transplant Dies

The University of Maryland Medical Center announced yesterday that David Bennett, the first successful recipient of a transplanted porcine heart, died at the age of 57.  An exact cause of death was not provided, though the physicians noted that his condition had been deteriorating over the previous several days.

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Surgeons at the University of Maryland Medical Center perform a pig-to-human transplant of a genetically modified porcine heart.

Milestone: Human Patient Receives Pig Heart Transplant

In a breakthrough years in the making, 57-year-old Dave Bennett has become the first human recipient of an organ from a genetically edited porcine donor.  The nine-hour procedure took place at the University of Maryland Medical Center under the leadership of surgeon Bartley Griffith.  Bennett, who began experiencing severe chest pain in October, was not eligible to receive an artificial heart pump or human heart transplant.  Knowing it was his best chance at survival, he agreed to the experimental surgery, and in the process has made history.

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Male doctor in surgical clothes looking at vertebral mri scan headshot

Swine Brain Development as a Research Model for Human Neurology

Humans and swine are known to have great similarities when it comes to anatomy and physiology, making swine an excellent model for research. This article is very interesting because it shows that early swine brain development is very similar to that of humans. It is intriguing to see how these animals compare to children (both at early ages and weights) in their MRI imaging. It is always great to be able to have the research be directly applicable to humans, because the diagnostic tool is one that is being used with people currently. Humans have MRIs done easily and it is something that can easily be instituted to help diagnose children with neurologic disorders. This study focused on body weight rather than age when it came to matching the children to the pigs, and it was found that this method of matching between animal and human worked out very well. There was a little bit of variation in certain chemical levels (CBF) that were being measured but that may also be linked to the anesthesia drugs that were used to anesthetize the animals. This research is very promising and will certainly help future children.

At Animal Biotech, we take great pride in the part that we’ve played in this sort of research. We not only provide live research swine and porcine tissue: we’re also here to offer our expertise on the proper care and housing of live animals.

Contact us today to learn how we can assist you in your next project.

pigs feeding

The Pig as a Model for the Study of Obesity and of Control of Food Intake

This research study published in the Yale Journal of Biology and Medicine found that people and swine are very similar physiologically in the way that they store fat, and in the size of their fat cells. Scientists are studying the genetics involved in porcine that are lean versus porcine that show much more fat storage. With obesity being a large problem with the human population these days, as well as people’s desire to achieve healthy weights, this research is critical to attaining our collective physical fitness goals. It is fortunate that swine are so similar to people in their fat storage methods.

For more than 30 years, Animal Biotech has helped research teams do this kind of work by providing live porcine models and porcine tissue.  In addition, we also offer clients expertise in the proper testing, care and housing of live animals.

Contact us today to learn how we can assist you in your next project.

Man's hand holding a stent between forefinger and thumb in front of his eye. Selective focus on the stent.

Thrombectomy Study in Pigs

Stents have long been a part of the lives of people. It is critical to keep clots and emboli in check to maintain the vascular health of people. Stent retriever mechanical thrombectomy is used standardly in treatment of strokes. The research done in this article on thrombectomy in acute stroke treatment is groundbreaking. The NeVa thrombectomy device is showing that it is able to collect and therefore remove large clot occlusions from the vascular system and achieve near-full to full reperfusion. The design of the device lends itself very well to capturing these clots. Swine are the model of choice for this study because their vascular system so closely matches the human vascular system.

We’re proud of the work our animals help researchers accomplish and look forward to contributing research swine to help in similar breakthroughs in the future.

In addition to offering live porcine models and porcine tissue, we’re also happy to offer clients our expertise in selecting the right animal model and/or animal tissue to utilize in their research.

Contact us today to learn how we can help you make your next discovery with the help of our high-quality animal models and tissues.

Anterior Cruciate Ligament in x-ray view

Comparison of Domestic Pig and Human Cruciate Ligaments

This research published in the Journal of Anatomy was done to compare human and porcine cruciate ligaments (namely the ACL and PCL) in their form and function.  The similarity of these two ligaments between people and swine are amazing.  It was noted, however, that the pig and the person differ in their gaits and it is difficult to fully match their movements and tensions on the ligaments.  Still, researchers are finding that people and swine are similar enough to be able to compare them on many other levels and their findings will benefit people with ligament injuries with further research.

Animal Biotech is pleased to play a role in this sort of research, offering live research swine and porcine tissue – along with expertise on proper animal care – to the biomedical world. Contact us today to learn how we can assist you with your next project.

Porcine Skin Graft on Human

Xenotransplantation: The Future of Skin Grafts

Xenotransplantation, transplanting animal’s organs into humans, has been studied in research for a long time and is the wave of the future.  Human-to-human organ donation is always in high demand and is very often difficult to procure in a timely fashion to save lives.  Being able to implement animal-to-human transplantation on a routine basis would make saving human lives much easier.  This article speaks of research in porcine skin transplants.  Skin is the largest organ of the body and is critical in the immune system.  Currently skin grafts come from human cadavers and patients that elect to have excess skin removed.  Patients that have been badly burned are always in need of skin grafts.  Porcine skin is incredibly similar to human skin with the exception of the fact that porcine skin produces a sugar that humans do not.  Through genetic modification, this sugar production in the porcine skin has been deleted so it is more conducive to human transplantation. 

This is yet another example of how porcine tissue models help biomedical research. In addition to the live animal models and porcine tissue we provide, we also offer clients expertise in the proper testing, care and housing of live animals.

Contact us today to learn how we can help you with your next project.

Live Animal Model: Pigs in Virus Research

Corona Virus

Research swine are playing an important role in the global fight against COVID-19, with live animal models helping to both create a vaccine and address the worldwide ventilator shortage.

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