An acellular cholecyst extracellular matrix (p-CEM) of porcine origin was prepared using anionic biological detergent and the healing potential compared with commercially available collagen sheet (b-CS) and open wound (C) in full-thickness skin wounds in rats.
Healing was evaluated on the basis of wound contraction, gross, hematological, immunological and histopathological observations. It was found that p-CEM had healing potential and was shown to have a better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.
This study illustrates the better healing qualities of porcine extracellular matrix when compared to commercially available collagen sheets and open wound in full-thickness skin wounds in rats.
— From Porcine cholecyst derived extracellular matrix (p-CEM) for reconstruction of full thickness skin wounds in rats. Poonam Shakya et al. Wound Medicine, Vol 10-11, December 2015, Pages 23-31. Copyright 2015 Elsevier B.V.
This research is just the latest study using porcine materials to advance medical treatment. Past studies have used pig models to look at repair to damaged hearts and genome reprogramming.
At Animal Biotech, we’re proud to be a part of this kind of work. For more than 20 years, we have supplied the biomedical research community with live porcine models and post-mortem tissues, along with expert consultation and information. Contact us today to find out how we can assist you in your work.
Heart disease is a leading cause of death in the US today and patients that survive a myocardial infarction have a low five year survival rate. Therefore there is a great need for regenerative approaches for stimulating repair.
Gene electro transfer (GET) to the left ventricular myocardium is a promising technique for delivery of therapeutic genes for the treatment of ischemia, myocardial infarction and heart failure directly to the effected myocardium. In this study a small animal model (rat) and a large animal model (porcine) were used for gene delivery to non-ischemic and ischemic left ventricular myocardium.
Gene expression was evaluated histologically for location of expression within the myocardium as well as quantitatively via ELISA. These animal models allow for the evaluation of therapeutic potential of particular gene delivery as well as translation to clinical settings.
— From Gene Electro Transfer to Left Ventricular Myocardium in Rat and Porcine Models by A.A. Bulysheva, B. Hargrave, N. Burcus, C.G. Lundberg, L. Murray, and R. Heller.
Past studies have shown post mortem porcine tissue effective in studying bone regeneration and other human health issues.
Animal Biotech is proud to be a part of this kind of work. For over 25 years, we have helped the biomedical research community by supplying it with live high quality research porcine models as well as high quality post mortem porcine tissues, organs, and glands. Animal Biotech also supplies information, consultation and training on husbandry, testing, housing and uses of live animals. Contact us today to learn more about how we can assist you in your work.