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Monthly Archives: November 2015

Can Rats and Pigs Help Mend Damaged Hearts?

Heart disease is a leading cause of death in the US today and patients that survive a iStock_000003693823_Smallmyocardial infarction have a low five year survival rate. Therefore there is a great need for regenerative approaches for stimulating repair.

Gene electro transfer (GET) to the left ventricular myocardium is a promising technique for delivery of therapeutic genes for the treatment of ischemia, myocardial infarction and heart failure directly to the effected myocardium. In this study a small animal model (rat) and a porcine model were used for gene delivery to non-ischemic and ischemic left ventricular myocardium.

Gene expression was evaluated histologically for location of expression within the myocardium as well as quantitatively via ELISA.  These animal models allow for the evaluation of therapeutic potential of particular gene delivery as well as translation to clinical settings.

— From Gene Electro Transfer to Left Ventricular Myocardium in Rat and Porcine Models by A.A. Bulysheva, B. Hargrave, N. Burcus, C.G. Lundberg, L. Murray, and R. Heller

 Past studies using pig models have given researchers new insights into cancer treatment and detection.

At Animal Biotech, we’re proud to be a part of this kind of work. For more than two decades, we have worked with the biomedical research community by supplying it with live porcine models and post-mortem tissues, as well as information and consultation. Contact us today to find out how we can assist you in your work.

 

What Porcine Enzymes and Mice Tell Us About Blood Brain Barrier Dysfunction

iStock_000012327217_SmallChronic obstructive pulmonary disease (COPD) shows progressive, irreversible airflow limitation induced by emphysema and lung inflammation. The aim of this study was to determine if COPD conditions induce blood-brain barrier (BBB) dysfunction.

They found that intratracheal administration of porcine pancreatic elastase induced alveolar enlargement, increased neutrophil numbers in bronchoalveolar fluid and decreased blood oxygen saturation in mice at 21 days post inhalation. At the same time BBB permeability to sodium fluorescein and Evans blue albumin was markedly increased concluding that COPD conditions are associated with risk for BBB impairment.

— From Elevated permeability of the blood-brain barrier in mice intratracheally administered porcine pancreatic elastase by Fuyuko Takata, Koji Tominaga, Mitsuhisa Koga, Shinya Dohgu, Koujiro Futagami, Atsushi Yamauchi, Yasufumi Kataoka

This study shows one of the many ways porcine models can aid in human health breakthroughs. In the past, researchers have used porcine  tissue to repair human tendons.