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How Porcine Cells Contribute to Restorative Therapies

porcine cells

Research swine are contributing to research studies that focus on restorative therapies to replace lost or diseased human tissues.

While the amount of suitable human cells for transplantation is lacking, porcine cells offer researchers a suitable, and much more available, alternative.

In 2014, researchers from the University of Pittsburgh found that cells derived from porcine organs – in this case, bladders – could work with human stem cells help build muscles in the legs of five men who had suffered severe injuries, including two soldiers injured by IEDs.

All five had suffered from nearly 60 percent to 90 percent of leg muscle loss, and had undergone surgery and physical therapy, with no success.

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How Porcine Islet Cells Could Help Treat Diabetes

porcine islet cells

Research swine are playing a substantial role in uncovering new methods of treating diabetes.

Porcine islet cells are an integral part of the microislet cell encapsulation method because there is an unlimited source of porcine pancreas cells as compared to human donor pancreatic islets.

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Xenotransplantation: How Pig Organs Could Be Transplanted into Humans

Pig organs research

The concept of xenotransplantation between humans and pigs is not new, but it’s one that’s faced some hurdles on the road to becoming a viable organ transplant method.

The key concern was that the human recipient could contract serious – if not fatal – zoonotic diseases from pig organs via porcine endogenous retroviruses (PERVS).

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Pig Lumbar Spines Used for Pedicle Screw Testing

Pedicle ScrewsPedicle screws have been the standard method of treatment of spinal diseases.

However, these screws can loosen over time after placement during surgery, which makes them a less-than-ideal choice.

But how can surgeons improve on this practice? The answer may lie within research swine. More specifically, within pig lumbar spines.

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Studying Skin Permeation with Porcine Tissue Models

Porcine SkinSkin permeation studies are extremely important in predicting percutaneous penetration, and porcine tissue models have proven very important in such research.

A recent study conducted at the University College of London compared skin parallel artificial membrane permeation assay (PAMPA), porcine skin and human skin in the permeation of compounds topically placed on each tissue/artificial tissue.

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Determining the Presence of Brown Adipose Tissue in Porcine Models

adipose cell on microscopeIf there’s one thread that runs through all our blog posts, it’s the physiological similarity between pigs and humans, a fact that makes the porcine model extremely useful in biomedical research.

For example, there’s the study conducted by researchers at South China Agricultural University and the University of Hawaii at Manoa that looked for the presence of brown adipose tissue (BAT) in pigs.

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Porcine Model Used for Wireless Capsule Endoscopy Research

Endoscopy Capsule Research using Porcine TissueWireless capsule endoscopy has been very helpful in making advances in the world of endoscopy, but this work has always been limited to superficial tissue.

However, a there is a new method of pairing ultrasonography with the wireless capsule, allowing doctors to view deeper levels of tissue and therefore have a clearer view of all the tissues involved in the endoscopic procedure.

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Porcine Model Used for Acute Lung Injury Research

porcine model for lung researchThe porcine model has proved to be helpful in establishing the therapeutic effects of mesenchymal stem cells (MSC) in reducing the inflammatory response during acute lung injuries.

In a study conducted at the Tripler Army Medical Center in Honolulu, researchers determined that pigs induced with severe traumatic lung injuries had decreased PVR/SVR levels two hours after treatment with MSCs.

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Finding a Solution for Cardiac Failure with Porcine Heart Tissue

Porcine Tissue for Cardiac FailurePorcine heart tissue may prove extremely helpful in finding a solution for cardiac failure.

The process of using detergents to decellularize and then recellularize porcine hearts with differentiated cells made from human patient specific pluripotent stem cells is an innovative area of research that may significantly change the prognosis for heart failure patients.

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