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Porcine Urinary Bladder Matrix Used to Treat Wounds

HAmericans spend more than $20 billion dollars a year on wound care, a figure that’s exacerbated by factors such as infections, repeated surgeries and extended hospital stays.

With that in mind, researchers are seeking innovative ways to enhance wound management. One such method is the porcine urinary bladder matrix.

Two recent studies have shown the effectiveness of porcine tissues in treating wounds in both humans and other animals.

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Microwave Ablation Study Using Porcine Liver

tissue shipment

Tissues prepared for shipment.

As we discussed last month, abalation is a method used in treating liver tumors. Our previous blog post looked at thermal abalation and porcine liver tissues.

This week, we’ll look at microwave abalation (MWA) in liver tumor treatments and a study by Italian researchers published in 2015 in the Journal of Cancer Surgery.

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Porcine Models Used to Study Radiosurgical Ablation of the Renal Nerve

porcine cadaverAbout 75 million Americans have hypertension, a condition that can lead to stroke, heart failure, kidney disease and elevated risk for heart attack.

Treating this condition can be frustrating. Only about half of all people with hypertension have the disease under control.

New research published earlier this year in the journal Cureus looked at the efficacy of treating refractory hypertension through radiosurgical ablation of the renal nerve.

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Studying Benign Periablational Enhancement in Porcine Liver Model

iStock_000003693823_SmallThermal ablation is an important technique in treating liver tumors and metastases. New research into this treatment conducted in Germany relied on porcine liver models to test ablation methods.

This study was conducted by researchers from University Medicine Berlin and Martin Luther University in Halle, and published in April in the Journal of Cellular Biology.

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Porcine Tissue Remodeling & Ingrowth

Porcine Tissue Remodeling & IngrowthSurgeons that perform tendon and ligament replacements are always searching for materials that can mimic the performance and load transmissions of the native material.

As often happens, these searches turn to porcine tissue to approximate human tendons.

In a U.S. patent application filed in 2016, LifeCell Corporation of Branchburg, NJ describes a study using a porcine acellular tissue matrix – derived from porcine skin – that was implanted into a human.

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Biocompatible Mesh Graft from Porcine Dermal Tissue

porcine dermal tissueThe cells that make up our bodies are surrounded by an extracellular matrix – ECM – which provides support for the cells.

When there is damage to the cells, tissue must be regenerated. This regeneration depends on a series of physiological events.

The first stage of this process is the inflammatory phase. After many other cells migrate to the damaged site, the differentiated cells produce and deposit new extracellular matrix.

Studies, such as the one published last year by LifeCell Corporation in New Jersey, have used porcine dermal tissue to make a biocompatible mesh to repair multiple damaged tissues, while minimizing infections or adhesions.

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A Study of Ultrasound Elastography Using Porcine Renal Tissue

Animal Models with Porcine Renal TissuePorcine renal tissue is useful in studying ultrasound elastography, a method of measuring the graft health of a transplanted kidney.

A recent study by researchers at the University of British Columbia found that blood pressure plays a role as a confounding factor in measuring the elasticity of the renal tissue.

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Studying Injectable Biomaterials on Porcine Tissue

injectable materials for porcine tissueAs we’ve pointed out multiple times on this blog, porcine tissue is used in research because of pigs’ biological similarities to humans.

That was the case yet again in a study conducted by researchers from the Departments of Chemical Engineering and Biological Sciences at Rowan University and the Department of Biomedical Engineering at Drexel University.

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Porcine Tissue Used for Vitreous Cryopreservation Research

PigletVitreous cryopreservation is a practice that allows for the preservation of biomaterials without the risk of excess ice accumulation.

Porcine tissues are an excellent model for this sort of research. There are many stresses – internal, thermal, residual – induced by the rapid cooling process of vitreous cryopreservation.

By using porcine tissues, researchers can fine-tune the methods used in cryopreservation and improve the process, which in turn will allow for effective preservation of larger materials.

Since porcine hepatic tissue is so similar to the liver tissue found in humans, it is an excellent tissue model for vitreous cryopreservation research. A recent study in China – published in the March 2017 edition of the International Journal of Heat and Mass Transfer — used porcine hepatic tissue to look at vitreous cryopreservation.

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